Antimicrobial therapy.pdf

Antimicrobial

Therapy in

Veterinary Medicine

Fifth Edition

Antimicrobial

Therapy in

Veterinary Medicine

Fifth Edition

Editors

Steeve Giguère

DVM, PhD, DACVIM

Professor, Large Animal Internal Medicine

Marguerite Hodgson Chair in Equine Studies

College of Veterinary Medicine

University of Georgia

John F. Prescott

MA, VetMB, PhD

Professor

Department of Pathobiology

University of Guelph

Patricia M. Dowling

DVM, MS, DACVIM, DACVCP

Professor, Veterinary Clinical Pharmacology

Veterinary Biomedical Sciences

University of Saskatchewan

Sons, Inc

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Library of Congress Cataloging-in-Publication Data

Antimicrobial therapy in veterinary medicine / [edited by]

Steeve Giguère, John F. Prescott, Patricia M. Dowling. – 5th ed.

p. ; cm.

Includes bibliographical references and index.

ISBN 978-0-470-96302-9 (hardback : alk. paper) – ISBN

978-1-118-67501-4 – ISBN 978-1-118-67507-6 (pub) – ISBN

978-1-118-67510-6 (pdf ) – ISBN 978-1-118-67516-8 (mobi)

I. Giguère, S. (Steeve) II. Prescott, John F. (John Francis),

1949- III. Dowling, Patricia M.

[DNLM: 1. Drug Therapy–veterinary. 2. Anti-Infective

Agents–therapeutic use. SF 918.A48]

SF918.A48

636.089

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2013012731

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1 2013

Contents

Contributors

Preface

xiii

Important Notice

Abbreviations

xvii

SECTION I

GENERAL PRINCIPLES OF ANTIMICROBIAL THERAPY

Antimicrobial Drug Action and Interaction: An Introduction

Steeve Giguère

Antimicrobial Susceptibility Testing Methods and Interpretation of Results

Joseph E. Rubin

Antimicrobial Resistance and Its Epidemiology

Patrick Boerlin and David G. White

Principles of Antimicrobial Drug Bioavailability and Disposition

J. Desmond Baggot and Steeve Giguère

The Pharmacodynamics of Antimicrobial Agents

Marilyn N. Martinez, Pierre-Louis Toutain, and John Turnidge

Principles of Antimicrobial Drug Selection and Use

105

Steeve Giguère

Antimicrobial Stewardship in Animals

117

J. Scott Weese, Stephen W. Page, and John F. Prescott

SECTION II

CLASSES OF ANTIMICROBIAL AGENTS

133

Beta-lactam Antibiotics: Penam Penicillins

135

John F. Prescott

Beta-lactam Antibiotics: Cephalosporins

153

John F. Prescott

Other Beta-lactam Antibiotics: Beta-lactamase Inhibitors, Carbapenems, and Monobactams

175

John F. Prescott

Peptide Antibiotics: Polymyxins, Glycopeptides, Bacitracin, and Fosfomycin

189

Patricia M. Dowling

Lincosamides, Pleuromutilins, and Streptogramins

199

Steeve Giguère

Macrolides, Azalides, and Ketolides

211

Steeve Giguère

Aminoglycosides and Aminocyclitols

233

Patricia M. Dowling

vi Contents

Tetracyclines

257

Jérôme R.E. del Castillo

Chloramphenicol, Thiamphenicol, and Florfenicol

269

Patricia M. Dowling

Sulfonamides, Diaminopyrimidines, and Their Combinations

279

John F. Prescott

Fluoroquinolones

295

Steeve Giguère and Patricia M. Dowling

Miscellaneous Antimicrobials: Ionophores, Nitrofurans, Nitroimidazoles, Rifamycins, and Others

315

Patricia M. Dowling

Antifungal Chemotherapy

333

Steeve Giguère

SECTION III

SPECIAL CONSIDERATIONS

357

Prophylactic Use of Antimicrobial Agents, and Antimicrobial Chemotherapy for the Neutropenic Patient

359

Steeve Giguère, Anthony C.G. Abrams-Ogg, and Stephen A. Kruth

Performance Uses of Antimicrobial Agents and Non-antimicrobial Alternatives

379

Thomas R. Shryock and Stephen W. Page

Antimicrobial Therapy of Selected Organ Systems

395

Patricia M. Dowling

Antimicrobial Therapy of Selected Bacterial Infections

421

Steeve Giguère

Antimicrobial Drug Residues in Foods of Animal Origin

431

Patricia M. Dowling

Regulation of Antimicrobial Use in Animals

443

Karolina Törneke and Christopher Boland

SECTION IV

ANTIMICROBIAL DRUG USE IN SELECTED ANIMAL SPECIES

455

Antimicrobial Drug Use in Horses

457

Steeve Giguère and Tiago Afonso

Antimicrobial Drug Use in Dogs and Cats

473

Jane E. Sykes

Antimicrobial Drug Use in Cattle

495

Michael D. Apley and Johann F. Coetzee

Antimicrobial Drug Use in Mastitis

519

Sarah Wagner and Ron Erskine

Antimicrobial Drug Use in Sheep and Goats

529

Chris R. Clark

Antimicrobial Drug Use in New World Camelids

541

Christopher K. Cebra and Margaret L. Cebra

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