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haematology in
critical care
a Practical handbook
edited by jecko thachil and quentin a. hill
 
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Haematology
in Critical Care
A Practical Handbook
EditEd by
Jecko Thachil, MRCP, FRCPath
Consultant Haematologist
department of Haematology
Central Manchester University Hospitals NHS Foundation trust
Manchester, UK
Quentin A. Hill, MRCP, FRCPath
Consultant Haematologist
department of Haematology
Leeds teaching Hospitals NHS trust
Leeds, UK
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this edition first published 2014
© 2014 by John Wiley & Sons, Ltd.
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apply for permission to reuse the copyright material in this book please see our website at
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All rights reserved. No part of this publication may be reproduced, stored in a retrieval system, or
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the contents of this work are intended to further general scientific research, understanding, and
discussion only and are not intended and should not be relied upon as recommending or promoting
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the publisher and the author make no representations or warranties with respect to the accuracy or
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Library of Congress Cataloging-in-Publication Data
Haematology in critical care : a practical handbook / edited by Jecko thachil, Quentin A. Hill.
p. ; cm.
includes bibliographical references and index.
iSbN 978-1-118-27424-8 (cloth)
i. thachil, Jecko, editor.
ii. Hill, Quentin A., editor
[dNLM:
1. Hematologic diseases–diagnosis–Handbooks.
2. Hematologic diseases–therapy–
Handbooks.
3. Critical Care–methods–Handbooks.
4. Hematology–methods–Handbooks. WH 39]
RC633
616.1′5–dc23
2014005978
A catalogue record for this book is available from the british Library.
Wiley also publishes its books in a variety of electronic formats. Some content that appears in print may not
be available in electronic books.
Cover images: blood film images – courtesy of Quentin A. Hill; iCU monitor – iStockphoto/© flubydust;
blood bag – iStockphoto/© pictorico; respiratory mask – iStockphoto/© Juanmonino
Cover design by Andy Meaden
Set in 9/12pt Minion by SPi Publisher Services, Pondicherry, india
1 2014
Contents
List of Contributors, v
Preface, ix
Acknowledgements, x
12 Critical Care of Patients with a Congenital bleeding
disorder, 69
Vanessa Martlew
Section 3 Approach to Transfusion Problems
13 blood Components and their Contents, 77
Shubha Allard
14 transfusion Reactions, 86
Therese A. Callaghan
15 the Management of Non-traumatic Massive
Haemorrhage, 93
Nicola S. Curry and Simon J. Stanworth
16 Plasma Exchange, 100
Khaled El-Ghariani
Section 1 Approach to Abnormal Blood Tests
1 diagnostic Approach to Anaemia in
Critical Care, 3
Stephen F. Hawkins and Quentin A. Hill
2 Leukopenia, 9
Stephen F. Hawkins, Jecko Thachil
and Quentin A. Hill
3 thrombocytopenia in the intensive Care Unit, 12
Jecko Thachil
4 High blood Counts, 16
Quentin A. Hill
5 the Abnormal Clotting Profile, 26
Jecko Thachil
6 Understanding the blood Film, 31
Stephen F. Hawkins and Quentin A. Hill
Section 4 Approach to Red Cell Problems
17 Appropriate Haemoglobin in intensive Care, 107
Jonathan Wallis and Stephen Wright
18 Sickle Cell disease and thalassaemia in the Critical
Care Setting, 112
Andrew Retter and Jo Howard
19 Management of Patients Who Refuse blood
transfusion, 118
Derek R. Norfolk and Fran Hartley
Section 2 Approach to Coagulation Problems
7 Venous thromboembolism in intensive Care, 39
Sarah A. Bennett and Roopen Arya
8 Reversal and Monitoring of Anticoagulants, 45
Joost J. van Veen
9 disseminated intravascular Coagulation, 52
Jecko Thachil
10 Heparin-induced thrombocytopenia, 58
Jerrold H. Levy and Anne M. Winkler
11 thrombotic Microangiopathies, 62
Mari Thomas and Marie Scully
Section 5 Approach to White Cell Problems
20 infectious Complications in the immunosuppressed
Patient, 125
Tim Collyns and Elankumaran Paramasivam
21 Haematopoietic Stem Cell transplantation
(HSCt), 135
John Snowden and Stephen Webber
iii
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