Handbook of Toxicologic Pathology.pdf

Handbook of

Toxicologic Pathology

EDITED

WANDA M. HASCHEK

Department of Veterinary Pathobiology

College of Veterinary Medicine

University of Illinois at Urbana-Champaign

Urbana, Illinois

COLIN G. ROUSSEAUX

Department of Veterinary Pathology

Western College of Veterinary Medicine

University of Saskatchewan

Saskatoon, Saskatchewan

Canada

ACADEMIC PRESS, INC.

Harcourt Brace Jovanovich, Publishers

San Diego New York Boston

London Sydney Tokyo Toronto

This book is printed on acid-free paper. ©

No part of this publication may be reproduced or transmitted in any form or

by any means, electronic or mechanical, including photocopy, recording, or

any information storage and retrieval system, without permission in writing

from the publisher.

Academic Press, Inc.

San Diego, California 92101

United Kingdom Edition published by

Academic Press Limited

24-28 Oval Road, London NW1 7DX

Library of Congress Cataloging-in-Publication Data

Handbook of toxicologic pathology / [edited by] Wanda M. Haschek

Colin G. Rousseaux.

p. cm.

Includes index.

ISBN 0-12-330220-X

1. Toxicology-Animal models-Handbooks, manuals, etc.

2. Toxicology, Experimental-Handbooks, manuals, etc. I. Haschek,

Wanda M. II. Rousseaux, Colin G.

[DNLM: 1. Poisoning-pathology-handbooks.

QV 39 H23643]

RA1199.4.A54H36

1991

615.9-dc20

DNLM/DLC

for Library of Congress

91 -4604

CIP

PRINTED IN THE UNITED STATES OF AMERICA

8 7

5 4

3 2

This book is dedicated to our families, especially to our

spouses Sylvie Nicholson and Vincent F. Hock, without

whose support this seemingly endless task would never

have been completed.

Contributors

Numbers in parentheses indicate the pages on which the authors' contributions

begin.

C. Marcelo Aldaz (165), The University of

Texas M. D. Anderson Cancer Center,

Smithville, Texas 78957

Carl L. Alden (315), Human and Environmental

Safety, The Procter and Gamble Co.,

Cincinnati, Ohio 45239

Stephen A. Benjamin (983), Department of

Pathology, College of Veterinary Medicine

and Biomedical Sciences, Colorado State

University, Fort Collins, Colorado 80523

Timothy A. Bertram (195), The Procter and

Gamble Co., Miami Valley Laboratories,

Cincinnati, Ohio 45239

Patricia M. Blakley (937), Department of

Veterinary Physiological Sciences, Western

College of Veterinary Medicine, University of

Saskatchewan, Saskatoon, Saskatchewan S7N

0W0, Canada

Thomas J. Bucci (23), Pathology Associates,

Inc., National Center for Toxicological

Research, Jefferson, Arkansas 72079

Charles C. Capen (675), Department of

Veterinary Pathobiology, The Ohio State

University, Columbus, Ohio 43210

Russell C. Cattley 1 (279), Department of

Microbiology, Pathology, and Parasitology,

College of Veterinary Medicine, North

Carolina State University, Raleigh, North

Carolina 27606

Claudio J. Conti (165), The University of Texas

M. D. Anderson Cancer Center, Smithville,

Texas 78957

Dianne M. Creasy (829), Shell Research

Limited, Sittingbourne Research Center,

Sittingborne, Kent ME9 8AG, United

Kingdom

Ronald A.DeLellis (675), Department of

Pathology, Tufts University School of

Medicine, Boston, Massachusetts 02111

1. Present address: Department of Experimental Patholo

gy and Toxicology, Chemical Industry Institute of Toxicol

ogy, Research Triangle Park, North Carolina 27709

xix

Contributors

David C. Dodd (9), Fairfield Glade, Tennessee

38557

Michael J. Evans (37), Department of Internal

Medicine, University of Texas Medical

Branch, Galveston, Texas 77550

John L. Farber (71), Department of Pathology,

Jefferson Medical College, Thomas Jefferson

University, Philadelphia, Pennsylvania 19107

Victor J. Ferrans (539), Ultrastructure Section,

Pathology Branch, National Heart, Lung and

Blood Institute, National Institute of Health,

Bethesda, Maryland 20892

Paul M. D. Foster (829), Central Toxicology

Laboratory, Imperial Chemical Industries,

Macclesfield, Cheshire SK10 4TJ, United

Kingdom

Charles H. Frith (315), Toxicology Pathology

Associates, and Departments of Pathology,

and Pharmacology and Toxicology, University

of Arkansas for Medical Science, Little Rock,

Arkansas 72211

Fletcher F. Hahn (983), Lovelace Inhalation

Toxicology Research Institute, Albuquerque,

New Mexico 87185

Wanda M. Haschek (761), Department of

Veterinary Pathobiology, College of Veterinary

Medicine, University of Illinois at Urbana-

Champaign, Urbana, Illinois 61801

Eugene Herman (539), Division of Drug

Biology, Food and Drug Administration,

Washington, D.C. 20204

Paul K. Hildebrandt (143), PATHCO, Inc.,

Ijamsville, Maryland 21754

Richard D. Irons (389), Molecular Toxicology

and Environmental Health Sciences Program,

School of Pharmacy and Department of

Pathology, School of Medicine, University of

Colorado, Denver, Colorado 80262

Webster S. S. Jee (489), Department of

Anatomy, Division of Radiobiology, College

of Medicine, University of Utah, Salt Lake

City, Utah 84112

Elizabeth H. Jeffrey (49), Institute for

Environmental Studies, Department of

Veterinary Biosciences, and Medical College,

University of Illinois at Urbana-Champaign,

Urbana, Illinois 61801

Andres J. P. Klein-Szanto (165), Department of

Pathology, Fox Chase Cancer Center,

Philadelphia, Pennsylvania 19111

Adalbert Koestner (625), Department of

Pathology, Michigan State University,

East Lansing, Michigan 48824

Magda A. M. Krajnc-Franken (421), Laboratory

for Pathology, National Institute of Public

Health and Environmental Protection,

3270 BA Bilthoven, The Netherlands

C. Frieke Kuper (421), CIVO-TNO Toxicology

and Nutrition Institute, Zeist, The Netherlands

Marlene E. Kyle (71), Department of Pathology,

Jefferson Medical College, Thomas Jefferson

University, Philadelphia, Pennsylvania 19107

Robert W. Leader (1), Center for Environmental

Toxicology, Michigan State University, East

Lansing, Michigan 48824

Daniel S. Longnecker (253), Department of

Pathology, Dartmouth Medical School,

Hanover, New Hampshire 03756

Robert R. Maronpot (91), National Toxicology

Program, National Institute of Environmental

Health Sciences, Research Triangle Park,

North Carolina 27709

Kristen J. Nikula (983), Lovelace Inhalation

Toxicology Research Institute, Albuquerque,

New Mexico 87185

Stata Norton (625), Department of

Pharmacology, Toxicology, and Therapeutics,

University of Kansas Medical Center, Kansas

City, Kansas 66103

James A. Popp (279), Department of

Experimental Pathology and Toxicology,

Chemical Industry Institute of Toxicology,

Research Triangle Park, North Carolina 27709

Barbara E. Powers (983), Department of

Radiological Health Sciences, Colorado State

University, Fort Collins, Colorado 80523

Colin G. Rousseaux (131, 937), Department of

Veterinary Pathology, Western College of

Veterinary Medicine, University of

Saskatchewan, Saskatoon, Saskatchewan S7N

0W0, Canada

Zadok Ruben (131), Department of Toxicology

and Pathology, Hoffman-LaRoche, Inc.,

Nutley, New Jersey 07110

Henk-Jan Schuurman (421), Laboratory for

Pathology, National Institute of Public Health

Plik z chomika:

Inne pliki z tego folderu:

Inne foldery tego chomika: